منابع مشابه
Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling
Glypican-5 (GPC5) is one of the six members of the glypican family. It has been previously reported that GPC5 stimulates the proliferation of rhabdomyosarcoma cells. In this study, we show that this stimulatory activity of GPC5 is a result of its ability to promote Hedgehog (Hh) signaling. We have previously shown that GPC3, another member of the glypican family, inhibits Hh signaling by compet...
متن کاملSonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation.
BACKGROUND AND PURPOSE Sonic hedgehog (Shh) protein is required for the maintenance of neural progenitor cells (NPCs) in the embryonic and adult hippocampus. Brain ischemia causes increased proliferation of hippocampal NPCs. We therefore examined whether Shh regulates the increase in proliferation of NPCs after ischemia/hypoxia. METHODS Male SV129 mice were exposed to a 20-minute middle cereb...
متن کاملIndian hedgehog (Ihh), one of the three mammalian hedgehog (Hh) proteins, coordinates proliferation and differentiation of chondrocytes during endochondral bone
Much of the vertebrate skeleton arises from a cartilage template, which subsequently undergoes endochondral bone formation (Erlebacher et al., 1995; Hinchcliffe and Johnson, 1990). At the earliest stage of this process, mesenchymal cells condense to form a cartilage anlage. Initially, all chondrocytes within the anlage proliferate. Thereafter, cells in the center of this structure exit the cell...
متن کاملAttenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells
Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat). In a pancreatic ductal adenocarcinoma (PDAC) cell line PANC-1 and transfected HEK293a cells Hhat localized to the endoplasmic reticulum. siRNA k...
متن کاملIndian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.
The mechanisms that control cell proliferation and cell differentiation during morphogenesis of the endochondral skeleton of vertebrates are poorly understood. Indian hedgehog (Ihh) signaling from prehypertrophic chondrocytes has been implicated in the control of chondrocyte maturation by way of feedback control of a second secreted factor parathyroid hormone-related peptide (PTHrP) at the arti...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2002
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc846